40HzGAMMASTIMULATOR
An open-source tool for exploring 40Hz auditory gamma entrainment.
For research, experimentation, and personal curiosity.
DESIGNED FOR PRECISION & SAFETY
This tool was built to closely follow the parameters from key peer-reviewed studies. The goal is to provide a precise and safe experience for everyone.
This web implementation strives for sample-accurate timing to minimize jitter. Consistent 40Hz stimulation is critical for entrainment, and this tool is carefully designed to maintain that frequency.
The tool includes volume calibration, smooth fade-in/out for sessions and breaks, and clear usage guidelines to ensure a safe and pleasant experience.
MIT sine pulses, human click trains, and binaural beats - each with different comfort levels and research support.
EXPERIENCE IT
Research-grade 40Hz gamma entrainment implementation
Improves comfort and tolerability
Reduces fatigue with regular pauses
Based on MIT research (Iaccarino et al., 2016). Uses 1ms pulses of 10kHz sine waves repeated at 40Hz. Most studied protocol for gamma entrainment.
THE SCIENCE BEHIND 40Hz
This project is based on the methods and findings from the following foundational studies.
PRIMARY SOURCES
Demonstrated that 40Hz sensory stimulation reduced amyloid-β in mouse models of Alzheimer's disease, restored gamma oscillations, and improved microglial response to plaques.
KEY FINDING: 40Hz stimulation can potentially slow or reverse Alzheimer's pathology through neural entrainment.
Showed that combined auditory-visual 40Hz stimulation is safe in humans, produces measurable changes in neural oscillations via EEG, and demonstrates preliminary cognitive improvements.
KEY FINDING: 40Hz stimulation is safe and effective in human subjects with measurable neurological effects.
Feasibility and pilot study in mild probable Alzheimer's dementia patients, demonstrating safety and preliminary efficacy of gamma frequency sensory stimulation.
KEY FINDING: 40Hz stimulation shows promise in Alzheimer's patients with good safety profile.
SUPPORTING LITERATURE
Demonstrated that gamma entrainment binds higher-order brain regions and offers neuroprotection.
DOI: 10.1016/j.neuron.2019.04.011Short-term effects of rhythmic sensory stimulation in Alzheimer's disease: An exploratory pilot study.
DOI: 10.3233/JAD-160081Brain responses to 40-Hz binaural beat and effects on emotion and memory.
DOI: 10.1016/j.ijpsycho.2017.07.010TECHNICAL REFERENCE
Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load. This protocol paper provides detailed technical specifications for 40Hz stimulation methods.
TECHNICAL REFERENCE: Detailed protocol for implementing 40Hz stimulation with specific parameters and safety considerations.
ABOUT THIS PROJECT
Hello! I'm Joona, and this is my hobby project.
It started as a personal Python script to replicate the stimuli used in exciting neuroscience research. This website is my best effort to make that experience accessible to anyone with a web browser. The original Python script is available on GitHub. No guarantees re the Typescript version but seems OK based on my testing.
The goal is to provide an open, accessible tool for researchers, biohackers, and anyone curious about the potential of gamma entrainment. If you're looking to build your own and want to get started easily, please check out the GitHub repo.